Hello everyone, I’m Procast~Summer has basically passed, and autumn is here, which means that the intensity of ultraviolet rays has gradually begun to drop. Although sun protection should be done all seasons, the intensity of ultraviolet rays is indeed lower in autumn and winter, so the whitening season is coming. So, today we will talk about the absolute first echelon of whitening ingredients: hydroquinone and its various derivatives.
1. Why is hydroquinone not recommended?
1. How does hydroquinone work?
Hydroquinone is hydroquinone, and the effect is one word To describe: “Meng”. It is prescribed by dermatologists for those who have a strong need for skin lightening and whitening. It is the strongest player in the field of “skin whitening” and topical whitening ingredients. Hydroquinone has a relatively strong inhibitory effect on tyrosinase. At a certain concentration, it will affect the metabolism of melanocytes and reduce the possibility of melanin production from within the skin. This is a tough hydroquinone, from Jae Heng’s magical hand-painted2. The safety of hydroquinoneHowever, the side effects of hydroquinone are also more obvious. Although medical science now considers that the risk is controllable at a certain concentration, it does not mean that there is no risk. For example, leukoplakia, its whitening effect is so strong that you may get leukoplakia, and there is a feeling of skin “discoloration”. Studies have also shown that there is a risk of cancer, but this aspect has to wait for more confirmation. Therefore, although there are also skin care brands abroad that have hydroquinone-containing essences, I do not recommend them to everyone.
3. Kanebo’s Rhododendron incident is also a wake-up call
Many students must still have impressions of Kanebo’s Rhododendron incident in 2013. At that time, Kanebo Bao did not do a comprehensive but safety study before putting azalea into use. As a result, many users had white spots (mostly short-term) after use, and the product was urgently removed from the shelves and recalled. Rhodendyl alcohol is a kind of hydroquinone derivative. Later research (seeing sitting or Kanebo’s own research and development classmates) is that rhododendrol can cause melanocyte damage at a certain concentration. Even death, causing white spots. This matter is also a reminder to everyone, sometimes it may not be a good thing to choose new raw materials as soon as possible. Rhododendron was listed by Kanebo in 2008, but it wasn’t until Kanebo that it was taken off the shelves in 2013. It is hard to believe that this was a case that was discovered suddenly. Finally, rhododendron alcohol and rhodod Phenibut on sale endron acid are completely different things. Azelaic acid, also commonly known as azelaic acid, can be used in skin care products, while rhododendron Alcohol won’t work.
Second, hydroquinone cannot be used, what should I do
When an ingredient is effective but too irritating, what should I do? To develop some of its derivatives, keep the “active” part, modify other parts to make it more in line with our requirements (effect, safety, permeability, etc.), the development of chemical drugs There is this strategy. The same is true for skin care products. VC is effective but unstable, so various VC derivatives have been developed. A acid has been clinically found to have some anti-aging effects, but it is too irritating, so skin care products use A Alcohol, A alcohol is still too strong, so a derivative of A alcohol was developed. The same is true for hydroquinone. Hydroquinone is too irritating and its safety is too problematic for skin care products, so everyone has tried to develop hydroquinone derivatives.
1. Anyone can use: SymWhite?? 377
The “377” that everyone usually says refers to a kind of raw material from the German raw material supplier Symise. SymWhite?? 377. Why is it called 377 instead of 488, 666? This is my hen~ 377 The name in the ingredient list is “Phenethyl Resorcinol”, but it should be noted that it is not in the ingredient list that there is Phenethyl Resorcinol. It does not necessarily mean that 377 is used. Other manufacturers also have this ingredient, and Symrise itself also has other ingredients containing this ingredient, such as SymWhite Plus. The usage amount of 377 is actually not as high as nicotinamide. The domestic regulation is <0.5%, so"" you"" really"" can’t"" just"" say"" that"" the"" content"" of"" this"" ingredient"" is"" low"" just"" because"" it"" ranks"" lower"" in"" the"" ingredient"" list."" it's"" useless."" the"" in"" vitro"" test"" data"" is"" good,"" so"" we"" don’t"" look"" at"" it"" (377:"" why"" don’t"" i"" look"" at"" the"" data?),"" the"" in"" vivo"" data"" actually"" looks"" pretty"" good,"" showing"" 0.5%"" the"" effect"" of"" 377"" is"" better"" than"" 1%"" kojic"" acid."" but"" the"" students"" who"" have"" been"" in"" touch"" with"" statistics"" a"" little"" bit"" will"" probably"" smile"" when"" they"" see"" this"" picture."" the"" error"" bar"" is"" too"" conspicuous,"" and"" it"" is"" really"" no"" problem"" between"" the"" two."">0.5%,>Source of screenshots: SymWhite 377 brochure produced in 2011and later Some of the “exclusive” materials mentioned are different. Dezhixin can sell this material t Buy Phenibut Online o different manufacturers, so you can think that this material can be used by everyone, and many domestic and foreign countries use this ingredient.Although the safety is now considered to be no problem, the raw material 377 is still irritating, which is more reflected in the “tingling” feeling, so pay more attention to it when you use it. It suddenly makes the concentration too high. As a result, if you can’t accept that product, no matter how good it is, it is useless. If you think the price of Dr.Ci:no is too high, then the Touzhen beauty lotion mentioned last Monday also contains 377, and the whitening essence of the civilian artifact Garnier also contains 377, which can be considered.
2, Estee Lauder Home: CL302
CL302 is written in the ingredient list as “dimethoxytolyl-4-propylresorcinol”, which is a bit long, originally called Nivitol?, according to the raw material supplier Unigen himself, was originally extracted from Viburnum, so it was also called Viburnum extract for some time. Later, Unigen and Estee Lauder Group had an exclusive cooperation, so in these years you have mainly seen it in the Estee Lauder Group brands, such as Estee Lauder, Clinique and so on. CL302 is essentially a resorcinol derivative. Although the addition of a large tail will affect the effect somewhat, it also improves safety. Skin care, safety comes first. From Unigen’s own research, the effect is still very significant: CL302 whitening effect introduced by Unigen Of course, the official effect is difficult to replicate in everyone’s actual situation, but it can be seen that this ingredient itself-at least in theory-is still very potential. 3. POLA: 4-ButylresorcinolPOLA is a more amazing brand in my eyes. It can be said that those who are very “forward-looking” have hit the “anti-glycation” point very early, but at the same time they are also willing to use the IQ tax of some whitening pills. However, it is still very good in whitening, 4-butyl resorcinol is its preferred whitening ingredient. According to POLA’s own data, the effect of 4-butyl-resorcinol is also very good, but looking at the POLA ingredient list, the amount of addition is not very surprising, and POLA prefers to combine it with AA2G Use, maybe it is better to find the effect after matching. In addition, 4-butylresorcinol is not only available for POLA. For example, K-Bright also has whitening products that also use 4-butylresorcinol. If you are interested in the ingredients and think POLA is too expensive, you can try these.
Hexylresorcinol is also a fairly large ingredient Phenibut on sale that is used now, and it is added to the Murad spot-lightening essence recommended some time ago it. (But there are other combinations) Hexyl resorcinol is also a resorcinol derivative, but the tail is more than POLA’s favorite 4-butyl resorcinol It’s a bit longer, and the more famous one is Synovea? HR from Sytheon. Looking at the official introduction, it not only has a whitening effect (also inhibits tyrosinase), but the decomposition products also have an anti-free radical effect, so it has a good effect on anti-aging. The screenshots are from the Sytheon brochureFrom the official data of Sytheon, 0.5% The effect of hexylresorcinol is very close to that of 2% hydroquinone. If there is such an effect, it is undoubtedly very expected. But as I just said, the results of official data may not be reflected in the products you buy, and may not be reflected in the effects of your use. Therefore, the expected value should be managed well. If you think Murad is too expensive, Neutrogena, RoC, Pond’s and other low-cost popular brands also use this ingredient in products, so you can also consider it.
To sum up: Which one should I buy?
In the article, I have put product pictures that I think are worth a try. Because of space reasons, there is no way to write a detailed introduction to each user experience, but the price is still marked. Here is another conclusion:
- Hydroquinone is still not recommended for 99% of students. I want to know “There are skin care products abroad, why don’t you recommend it? “This question itself has shown that your knowledge reserves are not enough to prepare you to use this product. Possible risks> possible benefits, “knowing that you don’t know” is also very important;
- have money And if you are willing to spend money on skin care products, choose a more expensive one. Although the effect is not necessarily better (but basically not worse with the example in this article), it has a richer sense of use and a bottle It’s really good-looking;
- Whitening itself requires a prerequisite: Don’t become darker, that is, take good sun protection. The whitening essence is like a manual cart, and the effect will be there after you work hard, but if you turn on the accelerator to reverse the car, it is too demanding.
- Hydroquinone derivatives are basically the first-line whitening ingredients, but it still takes time, and if possible, when used with other whitening ingredients such as nicotinamide, VC, etc., the effect will be better. Different angles to deal with the problem of whitening.