What is skin care science/whitening ingredient “377”? (Contains analysis of whitening principles)

Dr.Ci:Ciye launched “377 Whitening and Brightening Essence”, directly using the raw material name “377” as the product name, and claimed that the addition amount of 377 reached 1.8%, and the whitening effect was excellent. Internet celebrities from all walks of life are also vigorously promoting, so that “377” is a whitening material. So what is “377”? “377” is the abbreviation of the product name of a cosmetic raw material of Dezhixin Co., Ltd. The full name of the trade name: SymWhite? 377The chemical name: 4-(1-phenylethyl)-1,3-BenzenediolChinese name: Standard 4-(1-Phenethyl)-1,3-benzenediol, CAS-No.: 85-27-8. According to the State Food and Drug Administration document No. 71 in 2012, it can be used as a cosmetic raw material. The Chinese name of INCI included in the 2015 Edition Approved Catalogue of Cosmetics: Phenylethyl Resorcinol, and the English name: PHENYLETHYL RESORCINOL. Why is the raw material of Dezhixin Co., Ltd. so hot? First of all, let’s understand what kind of company Dezhixin is. Dezhixin Group is headquartered in Germany and is the world’s fourth largest manufacturer of daily chemical flavors, edible flavors, fragrance raw materials and cosmetic raw materials. Customers include perfume, cosmetics, food, beverage, pharmaceutical, health care products and pet food manufacturers, and are also engaged in research and development, procurement and providing solutions. Therefore, Dezhixin’s raw materials are an authoritative raw material supply company in the industry. To understand the whitening ingredien Phenibut powder wholesale ts, first of all, let’s take a look at the melanin production and whitening principles1. The formation of melanin1. Melanocytes-melanin Melanocytes exist in the basal layer of human epidermis, which can form melanin. Melanocytes account for about 4% to 5% of basal cells. Melanin is the biggest factor that determines the color of human skin. When the content of melanin is high, the skin changes from light brown to black. There is no difference in the distribution density of melanocytes. People of all skin colors are basically the same, with a total of about 2 billion in the whole body. The main reason for the difference in skin color among different races is the difference in melanosomes. The melanosomes in the keratinocytes of white people and yellow people mainly gather in the enveloped complex; most of the black people are distributed separately. Human skin color mainly depends on the ability of melanocytes to produce melanin. Under normal conditions, melanin can absorb excessive sunlight, especially ultraviolet rays, to protect the human body. If the melanin produced cannot be metabolized in time to accumulate and deposit on the epidermis, freckles, melasma or age spots will appear on the skin. The mechanism of melanin formation is shown in the figure.The formation of melanin must be There are three basic substances: Tyrosine is the main raw material for melanin production; Tyrosinase is the main rate-limiting enzyme for the Buy Phenibut Online conversion of tyrosine to melanin, which is a combination of copper and protein; Tyrosine is in tyrosine Melanin is produced under the action of enzymes, which is an oxidation process, which must be combined with oxygen to be converted into melanin. In summary, the currently recognized melanin formation pathway:Tyrosine?Dopa?Dopaquinone?Dopachrome?Dihydroxyindole?Ketoindole? Melanin2. Inhibition mechanism of melanin production-whitening mechanismThe basic principle of skin whitening and freckles removal. According to the basic principle of skin pigmentation, it is known that to make the skin tone even and fair, it needs to be reduced There are two main ways to accumulate melanin in the skin: inhibit the production of melanin and promote the rapid excretion of melaninUnderstand the specific principles of whitening, let’s take a look at how “377” achieves whitening of. As mentioned above, there are many whitening principles of whitening agents, of which inhibition of melanin production is the most effective way. “377” is this whitening principle. “377” is currently one of the most effective tyrosinase inhibitors. It inhibits the production of melanin by inhibiting tyrosinase. The development process of 377Hydroxystilbene compounds have been proven to be effective tyrosinase inhibitors. For example, resveratrol from the root of Veratrum pilaris and the bark of Siberian red pine; the stilbene derivative extracted from the core material of Phenibut powder wholesale the bread tree is 33 times that of kojic acid. But stilbene and stilbene are unstable, because the trans double bond between the two benzene rings is prone to isomerization reaction under irradiation, and the corresponding cis-stilbene is formed from this. More high molecular weight actinic products are generated and quickly decomposed. Pinus sylvestris (Pinus sylvestris) obtains 3,5-dihydroxystilbene and 3-O-methyl derivatives. They can inhibit the activity of tyrosine, but are unstable, so Chemical synthesis is needed to improve the structure of pinosin. The compound 4-(1-phenylethyl)-1,3-benzenediol with stable efficacy and structure is obtained, and the inhibitory effect on tyrosinase is 22 times that of kojic acid. In the analysis experiment of B16V melanocytes, it is the most effective in inhibiting melanin synthesis. Moreover, the MTT analysis experiment on B16V cells confirmed that the whitening effect of the compound did not stem from cytotoxicity. In vivo experiments in Asian populations have proved that this compound can effectively whiten human skin at a dosage level of 0.5%. Limitations of “377”The application of phenethyl resorcinol (377) in the formulation also has its limitations. It has the disadvantage of light instability. It is easy to chelate with metal ions, and it will gradually change from white to light yellow under light conditions, and eventually turn to pink. There are also technical problems such as low bioavailability. How to improve the stability of benzene Z-based resorcinol and increase the bioavailability of this ingredient is still a problem to be solved. Picture: Screening and structure evolution of synthetic 377 natural structure:Picture human body test of whitening effect